Dynamical quorum sensing: Population density encoded in cellular dynamics.

نویسندگان

  • Silvia De Monte
  • Francesco d'Ovidio
  • Sune Danø
  • Preben Graae Sørensen
چکیده

Mutual synchronization by exchange of chemicals is a mechanism for the emergence of collective dynamics in cellular populations. General theories exist on the transition to coherence, but no quantitative, experimental demonstration has been given. Here, we present a modeling and experimental analysis of cell-density-dependent glycolytic oscillations in yeast. We study the disappearance of oscillations at low cell density and show that this phenomenon occurs synchronously in all cells and not by desynchronization, as previously expected. This study identifies a general scenario for the emergence of collective cellular oscillations and suggests a quorum-sensing mechanism by which the cell density information is encoded in the intracellular dynamical state.

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عنوان ژورنال:
  • Proceedings of the National Academy of Sciences of the United States of America

دوره 104 47  شماره 

صفحات  -

تاریخ انتشار 2007